NFL Week 1 Odds: How to Bet on the Opening Week of the New NFL Season

This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports. The NFL season is finally here, and Week 1 kicks off Wednesday, giving fans and bettors an early start to the action. New coaches, new players, rookies and everything that the 2026 season brings is here. A Super Bowl rematch between the New England Patriots and Seattle Seahawks kicks off the action. Then, a NFC West rivalry travels down south to Australia. The Los Angeles Rams and San Francisco 49ers meet in Melbourne. The rest of the action begins Sunday. Josh Allen and the Bills take on the daunting Texans’ defense, the Packers visit the Vikings and the Eagles host the Commanders. Sunday night closes with the Cowboys facing the Giants in New Jersey. From spreads and moneylines to totals and player props, NFL Week 1 odds are ready and if you join DraftKings, FanDuel, BetMGM or any other sportsbooks, you can catch the best odds and new users promos. Here’s a look at the latest odds, key matchups and the best bets to consider as the NFL gets underway. FanDuel Bet $5, Get $350 in Bet Reset Tokens for 7 Days *Odds may differ each site* DraftKings Claim the New User Offer No Promo Code Needed *Odds may differ each site* Caesars Sportsbook Sign Up and Claim the Caesars Sportsbook Promo Code *Odds may differ each site* bet365 How to claim bet365 Promo with Bonus Code ‘FOX365’. *Odds may differ each site* BetMGM How to Sign Up and Claim the BetMGM Sportsbook Bonus Code​NFL Week 1 Odds: How to Bet on the Opening Week of the New NFL Season.