Missouri vs. Kansas Prediction, Odds, Pick For College Football Week 1

Kansas will host No. 23 Missouri on Friday in a Week 2 college football matchup on FOX. Missouri got off to a strong start in 2026, beating Arkansas-Pine Bluff 54-14 in Week 1. Former Ole Miss transfer quarterback Austin Simmons completed 17 of 19 passes for 252 yards and four touchdowns, as the Tigers piled up 562 yards of total offense. Running back Jamal Roberts had 13 carries for 46 yards and a touchdown, and will continue to handle the lead-back role, with Missouri star Ahmad Hardy still considered week-to-week as he rehabs from a gunshot wound. Meanwhile, Kansas opened its 2026 campaign with a dominant 51-6 win over Long Island in Week 1. Sophomore quarterback Isaiah Marshall threw for 246 yards and two touchdowns while adding 49 yards on the ground in his first career collegiate start. Marshall has big shoes to fill after Jalon Daniels threw for 4,985 yards and 36 touchdowns over the past two seasons, and he’ll now face his first Power 4 opponent as a starter. These two schools met last season, with Missouri earning a 42-31 win at home. The Tigers have now won four straight meetings in this rivalry. Can the Jayhawks flip the script in 2026? Let’s take a look at the odds for Missouri vs. Kansas at FanDuel Sportsbook as of Sept. 11. This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports. Moneyline Spread Over/Under From FOX Sports Research: Eli Drinkwitz has been reliable during his six seasons at Missouri, posting a 46-29 record. That success has carried over to spots like this one. As a ranked team facing an unranked opponent on the road, Missouri is 5-0 under Drinkwitz and has covered the spread in all five games. Even without star running back Ahmad Hardy, the Tigers have an experienced and reliable option in Roberts, who can handle a bigger workload on the road. Austin Simmons also looked impressive in his Missouri debut and his experience in a few big games at Ole Miss could prove invaluable. Missouri simply has more talent from top to bottom, and with Daniels no longer leading the Jayhawks’ offense, the Tigers have the edge. Take Missouri to cover the spread. How to Watch Missouri vs. Kansas​Get the latest odds, prediction and pick for the Week 2 Missouri vs. Kansas game, as well as information on how to watch.